Dissertation/Thèse

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2024
Thèses
1
  • LARISSA GABRIELLY DA SILVA MORAIS
  • EVALUATION OF EDUCATIONAL DYNAMICS IN TEACHING HUMAN PHYSIOLOGY IN THE POST-PANDEMIC CONTEXT

  • Leader : DAYANE PESSOA DE ARAÚJO
  • MEMBRES DE LA BANQUE :
  • DAYANE PESSOA DE ARAÚJO
  • JOSIANE DE CAMPOS CRUZ
  • PABLO DE CASTRO SANTOS
  • Data: 23 févr. 2024


  • Afficher le Résumé
  • The formation of a good basis for teaching human physiology allows the construction of critical thinking and clinical reasoning capable of using knowledge about the systems of the human organism and their integrations to establish body homeostasis, developing integral and effective problem solving . During the pandemic period, the educational configuration required changes in planning, objectives, a new understanding of the teaching-learning process, resulting in changes in educational paradigms both from the perspective of teachers and students. However, with the transposition of teaching paradigms and new educational skills at the expense of the Covid-19 pandemic, the following question arises: How is the educational dynamics of the physiology discipline configured in the post-pandemic context? Were there changes or continuity in the educational style that was already being implemented? The general objective of this research is to evaluate the educational dynamics in the teaching of human physiology in the post-pandemic context, outlining specific objectives such as: understanding the difficulties and potential seen as a result of transposing the teaching of human physiology from the virtual to the in-person environment; identify the teaching perspective regarding educational changes regarding the teaching of human physiology in the post-pandemic context; identify the student perspective regarding educational changes regarding learning human physiology in the post-pandemic context; know the methods used for teaching in the post-pandemic period, whether or not there is continuity in technological implementation and dynamic innovations implemented for teaching human physiology; assess whether knowledge of human physiology is being built according to the integration of body systems in order to instigate critical thinking and effective clinical reasoning for the training of good health professionals. This is a descriptive and exploratory study with qualitative and quantitative approaches. The placement locations consisted of two of the main public higher education institutions present in the state of Rio Grande do Norte and their respective campuses, which offer courses in the health area and have the subject of human physiology in their curricula. The study population was made up of university students and teachers who studied and taught, respectively, the discipline of human physiology during the years 2021 and 2022, in the four corresponding semesters, in the HEIs selected for the application of this research. Therefore, the research sample size was determined with the help of the digital calculator. The finite sample calculation was carried out following the variables to calculate the minimum sample size. Data collection took place through two questionnaires with different directions, one for students and one for teachers, with open and closed questions divided into categories of teaching, methodology and results, both seek to evaluate the teaching-learning process of human physiology, the presentation It can be in digital format via Google Forms and printed on A-4 paper, the participant chooses the format they want. The study population included university students and professors who are part of health courses in the HEIs selected for the research, who studied or taught, respectively, the human physiology discipline during the period from January 2021 to December 2022, encompassing the four corresponding semesters, who agreed to sign the Free and Informed Consent Form. Students and teachers who for some reason were excluded from the human physiology discipline or were on leave during the 2021 and 2022 academic semesters were excluded from the study.

2023
Thèses
1
  • Elanny Mirelle da Costa
  • ANTIBACTERIAL POTENTIAL OF MULUNGU EXTRACT (Erythrina velutina)

    AGAINST STRAINS OF GRAM POSITIVE AND GRAM NEGATIVE BACTERIA

  • Leader : LUCIDIO CLEBESON DE OLIVEIRA
  • MEMBRES DE LA BANQUE :
  • LUCIDIO CLEBESON DE OLIVEIRA
  • JOSÉ RODOLFO LOPES DE PAIVA CAVALCANTI
  • GEOVAN FIGUERÊDO DE SÁ-FILHO
  • Data: 6 févr. 2023


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  • Erythrina velutina, is a tree native to Brazil, known for its medicinal properties and easily
    found in the Northeast of the country, this plant is rich in alkaloids and flavonoids. The
    ethanolic extract of Erythrina velutina has gained more and more space, mainly due to its
    anxiolytic potential. In this sense, the objective of the present study was to evaluate the
    antibacterial potential of Mulungu leaf extract (Erythrina velutina) in strains of bacteria that
    cause various pathologies in humans. For this, extracts of the leaves of the plant in good
    condition, free of any deficiency and/or with signs of parasitism, were obtained, which were
    cataloged and labeled in plastic bags for further processing in the laboratory. The leaves of the
    species underwent numerous processes to reach the final result of the crude extract, which was
    used to evaluate the antibacterial activity of E.velutina leaves against clinical strains. The
    bacterial strains used came from standardized American Type Cell Culture (ATCC) collections,
    properly characterized morphologically, physiologically and biochemically, performed with

    Gram positive bacteria: saprophytic Staphylococcus, Staphylococcus aureus, and Gram-
    negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris and Klebsiella

    pneumoniae. Initially, all strains were reactivated in Brain Heart Infusion –BHI broth for 24 h
    to obtain turbidity equivalent to the standard 0.5 on the Mac Farland scale, which corresponds
    to a concentration of approximately 1.5 x 108 CFU/mL. Subsequently, antibiotics were used to
    use the positive control (C+) to inhibit bacterial growth and, as a negative control, 20 μL of
    distilled water. For analysis of the antibacterial potential of the extracts, the well technique with
    modifications was used. The results were read by checking the diameters of the halos in
    millimeters (mm), formed around the wells containing the extracts. Regarding the extract of
    Erythrina velutina, it was analyzed that there was no antimicrobial sensitivity in the strains, as
    there were no growths of halos in the petri dishes, in any of the concentrations in which there
    was dilution of the solid extract (4, 8, 16 and 32 mg. mL- 1). During the execution of the
    experimental stage, it was noticed that there was antimicrobial sensitivity only in the positive
    control group (C+). In view of this, it was possible to analyze that there was no antibacterial
    sensitivity in any of the strains tested, and it can be concluded that, according to the
    methodology used in this work, Erythrina velutina did not present antimicrobial potential
    against the strains tested within the concentrations used, thus, it was only possible to observe
    sensitivity against the antibiotics used for the control group. However, it is suggested that more
    research be carried out in order to investigate whether there is antibacterial potential of extracts
    made from other parts of the plant, in order to corroborate the data with existing studies in the
    literature and the findings in this research.

2
  • Antonia Isabelly Bezerra da Silva
  • EVALUATION OF THE ANTI-INFLAMMATORY POTENTIAL OF METHANOL EXTRACTS FROM CATINGUEIRA (Cenostigma bracteosum) AND CANAFISTULA (Senna trachypus)
  • Leader : JOSÉ RODOLFO LOPES DE PAIVA CAVALCANTI
  • MEMBRES DE LA BANQUE :
  • LUANNE EUGÊNIA NUNES
  • JOSÉ RODOLFO LOPES DE PAIVA CAVALCANTI
  • LUCIDIO CLEBESON DE OLIVEIRA
  • Data: 26 mai 2023


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  • The use of medicinal plants are ancient practices used by the population to prevent or treat various types of diseases. In the midst of attempts, man gradually acquired knowledge about plants, identifying among them which ones had a therapeutic effect. In the Brazilian Northeast, the use of medicinal plants for the treatment of diseases is widespread with plants easily accessible by the local population and many of these plants have not yet had their effectiveness scientifically proven. Taking into account that Catingueira (Cenostigma bracteosum) and Canafístula (Senna trachypus) are species used by the population and that there is little research about their therapeutic potential, the objective of this work was to evaluate the anti-inflammatory activity of these species. For this experiment, 24 adult Wistar rats of both sexes (180-250g) were used, divided into six groups with 4 (four) animals each, one group for negative control (animals with carrageenan), another for positive control ( with topical application of dexamethasone), two groups for formulations with catingueira extracts (Poincianella bracteosa) with concentrations of 1% and 10%, respectively, and finally, two groups for formulations with extracts of canafístula (Senna trachypus) with concentrations of 1 % and 10% respectively as well. The gel formulations were topically applied to the right hind paws shortly after the carrageenan injection. After the last measurement of edema, the animals were euthanized for collection and fixation of the hind paws in formalin and preparation of histological slides. It was possible to observe that the gels of the two species studied were effective in reducing the paw edema induced by carrageenan. In the histological evaluation, it was also possible to observe a decrease in neutrophils in the groups treated with catingueira. Thus, it is suggested that the studied species have anti-inflammatory potential.

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